Neuromodulators, such as Botox, Dysport, Xeomin, are injectables designed for reducing and removing small and big wrinkles on the face by relaxing certain facial muscles.

All neuromodulators are derived from Botulinum toxin. Differences between various brands are due to accessory proteins which surround toxin molecule. It is known that accessory proteins do not play a role in the action of a neuromodulator.

Some research has shown that accessory proteins can actually contribute to allergic reactions and building resistance from the body towards neurotoxin, where, with time, a client needs bigger dosages to achieve the same results. Resistance towards neurotoxin is rare, and if it develops, a switch to a different neuromodulator usually fixes the problem.

Let’s Talk About Dynamic and Static Wrinkles

Dynamic wrinkles develop due to a movement of facial muscles, such as laughing, crying, talking. Examples of dynamic wrinkles would be crows feet, forehead wrinkles, the 11s between brows, bunny lines on the nose, “smoker” lines around the mouth, cobblestone chin. Dynamic lines if not treated can become static lines, where they stay on the face all the time even if all the muscles are relaxed, and a person does not do any facial expression. Static lines are much harder to treat and eliminate than dynamic lines. develop due to a movement of facial muscles, such as laughing, crying, talking. Examples of dynamic wrinkles would be crows feet, forehead wrinkles, the 11s between brows, bunny lines on the nose, “smoker” lines around the mouth, cobblestone chin. Dynamic lines if not treated can become static lines, where they stay on the face all the time even if all the muscles are relaxed, and a person does not do any facial expression. Static lines are much harder to treat and eliminate than dynamic lines.

Treating Dynamic and Static Lines

Dynamic lines are best treated with Neuromodulators ( Botox, Dysport, Xeomin etc.). Other areas that can be effectively treated with neurotoxins are downturn mouth, slimming of the face, neckbands.

A small amount of neuromodulator is injected into the appropriate muscle to relax it. As a result, the muscle debulks, creating less intense movement in the treated area. The goal of the therapy is not to freeze the muscle, but to relax it. So the dosage of injected medication is crucial to effectively treat the area but still leave the client with normal movement in their face.

Static lines can certainly benefit from neuromodulator injection as well, but to eliminate static lines, a combination of neuromodulators and fillers is usually needed.

How Long Do Neuromodulator Injections Last?

On average, it takes up to 2 weeks for a full effect of neuromodulator to take place. It is important to know that the neuromodulator acts for 3-4 months, gradually dissolving from the body. So, it is important to come for a follow-up appointment in 2 weeks to see if any touch-up is needed. We also recommend scheduling your appointments every 3-4 months to keep your skin free of dynamic lines and to prevent appearance of static lines.

Other uses for Botulinum neurotoxins: hyperhidrosis, dystonia of neck spasms, muscle stiffness and spasms, headaches, to relax joints and improve circulation.

The Different Brands of Neuromodulators

All modulators are very similar with the same active ingredient: botulinum toxin. However, there are slight variations in terms of their onset, and their final result.

Botox® (onabotulinumtoxinA), Dysport® (abobotulinumtoxinA), and Xeomin® (incobotulinumtoxinA) are FDA approved and Health Canada approved for treatments of forehead lines between brows also known as the “11s.”

The use of botulinum toxin for other dynamic wrinkles is considered technically off-label. However, Botox®, Dysport®, and Xeomin® have shown in practice to be highly effective for all dynamic wrinkles and lines of the face and neck.

Botox®:

  • has the most of the complexing proteins.
  • takes up to 14 days to kick in
  • gives a stronger finish
  • usually does not migrate, up to 1cm



Dysport®

  • the molecule of botulinum toxin is also surrounded by complexing proteins, but with less weight which varies
  • kicks in faster, 3 to 10 days
  • gives a softer, more natural finish
  • can migrate and disperse further from the injection site

Xeomin®

  • has no complexing proteins, pure toxin, also known as “naked botox”
  • less likely to develop resistance to or cause allergy
  • start to work the next day, full effect kicks in 5 to 10 days
  • usually does not migrate

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